A co-worker is seriously considering switching back to Mac because so many apps are misbehaving in a mixed-DPI environment in Windows. Maybe if both your monitors are 4k you're okay, but it really sucks if 1 is 4k and the other isn't, such as when you have a laptop with an additional monitor.
I actually use two monitors with different scaling and it works just fine for me. That’s why I mentioned it. What apps is your friend having trouble with?