Although I confess I have only read the first chapter or so, the book sets out to convince its readers that many of the things that can go wrong in the human brain ought not to be thought of as bad choices so much as automobiles in need of a part replacement (this metaphor rings true today in the case of, say, depression, which can often be remedied with pharmaceuticals). This may sound rather weak (especially from the point of a prosecutor [1]), but when looking at the details, it starts to make sense in a lot of cases.
For example: in the middle ages, what do you think people thought schizophrenia was?