https://en.wikipedia.org/wiki/List_of_unsolved_problems_in_m...
Seriously though, I'm talking about something qualitative here. When I read about these side-channel attacks yesterday I had this crazy gut feeling about how exposed our technologies are to those who learn to understand them deeply.
There's an complementary kind of arrogance to the one you're suggested: "anything I don't understand couldn't possibly be a threat... since I could never easily exploit it, it'd be way too hard for someone else to."
But have you listened to the radiolab about the z-cash cryptography ritual? It's very enjoyable and has a spooky surprise ending: