The Delancey Street Foundation is an organization that has recuperated thousands of people who have hit rock bottom. And they do it without any government funding (they're self-supporting). One of the best examples of social entrepreneurship out there.

http://www.delanceystreetfoundation.org/

And if you're interested in the details of how the organization operates, I did some research and wrote about the organization on my blog:

http://nathanmarz.com/blog/mimi-silbert-the-greatest-hacker-...