I used to use Atom a lot but being that I regularly am pulling and investigating large files that was a deal breaker.
The biggest file I regularly work with in the editor is 10,631 lines long (I just checked, and it's longer than I thought). Atom works fine with it, including syntax highlighting, and cutting/pasting/typing/etc.
Actually...out of curiosity, I just opened up a ~110,000 line file (a log I had laying around). It seems to work fine. It took a little longer to open than it would in vim (which is effectively instant), but not as long as I would have expected. It was well under a second, and within my comfort zone for opening files. Switching tabs seems maybe a little more sluggish with it loaded, but not uncomfortably so.
I think I have to accept Atom into the category of editors that can work with pretty large files. I can't imagine having a source file any longer than that 10,000 line file I work with regularly (and I would never make a file that large, but historic codebases sometimes have weird things in them), but it seems like it'll work even if someone did.