1. Destroying a civilization isn't risk free. If you destroy a nearby star system that harbors life, you better be sure that your weapon can't be traced back to you, by either any observers, or by the survivors. (See Forge of God & The Anvil of the Stars[1] for a study of the latter.)
2. If you do subscribe to the Dark Forest game theory, and do have what you believe is an untraceable weapon of some kind, there's no reason not to sterilize every star system around you. Why would you wait until you've detected life? Send out self-replicating Saberhagen Berserker[2] probes and sterilize the galaxy. (Be sure you've got a good Friend-or-Foe system in place.)
[1] https://www.goodreads.com/book/show/464609.Anvil_of_Stars [2] https://www.goodreads.com/book/show/582675.Berserker