I'm brainstorming an idea where someone has created an RPG. The only way to succeed in this RPG is to master real-world knowledge. For example, Medicine or Healing may be an aspect of the game. For someone to achieve expert level in the game, they would have needed to prove to the game (through some mechanism) they have doctor-level knowledge.
Often we hear about applying game-tactics like achievements and leveling-up to real-world activities to keep people working toward their goals. What about putting real world study into an RPG to keep progress toward goals in the game?
Imagine World of Warcraft level obsession with mastering a dozen fields of science.