My favorite part of this story is how incredibly strong biases are toward existing hypotheses.
"Lichenologists all thought that the fungi in the partnership belonged to a group called the ascomycetes—so Spribille had only searched for ascomycete genes. Almost on a whim, he broadened his search to the entire fungal kingdom, and found something bizarre."
Sometimes we need to just throw our hypotheses out the window and look at all the data our tools can give us, especially now that sequencing is so cheap.