Yes. You just need to understand people, markets, and processes.
Any deep technology insight will be irrelevant -- the right advisors from your stuff (which you'll know who they are, since, as we said above, you can understand people -- including when they are full of shit or not), can explain it to you "like you are five".
Taleb makes a similar point described here that extends beyond the domains in the story:
One of the most successful traders to ever buy and sell green lumber – which is freshly cut wood – actually had no idea what he was trading. He spent his entire career trading green lumber career believing the product was just wood painted green, and not newly cut trees. His ignorance of the product had no impact on his ability to make money trading it. The term “Green Lumber Fallacy” was coined by Nassim Nicholas Taleb in his excellent book ‘Antifragile’, where he outlined a second similar situation: a star Swiss Franc trader who’s inability to locate Switzerland on the map didn’t hinder his ability to make money trading its currency.
https://www.pinnacle.com/en/betting-articles/betting-psychol...