As a result of this thread I have tried the Nylas mail client which has a javascript UI, and I am very pleasantly surprised by just how smooth the UI is.
Honestly, if I could use it without a Nylas account I would very seriously consider it as a Thunderbird replacement.
From reading the original email thread it also looks like the Thunderbird guys are paying attention to Nylas.
VSCode and Slack are two other Electron apps with snappy UIs. Though I commend the devs on their snappy UIs, both those apps churn the CPUs and consume crazy amounts of memory. They absolutely kill the battery on laptops and make other applications unusable.
I do not want my mail client or any other app that should be always running in the background to be written in Electron.
That's a pity. Given that they are exactly aiming for mobile applications though I really hope they will keep these issues in mind though and make informed decisions on this.