One example could be focusing on throughput instead of startup latency which could yield distorted outcomes for real world apps, or mostly app code that is mostly early-bound style OO code/monomorphic functional code vs code that is hostile to class shape analysis/PIC.
It seems in the last few years, especially with the idea of Web competing with native with stuff like asm.js for games, there was a focus on maximize throughput, but it's rare your typical interactive web app is running code that benefits from that.
