As much as I agree with the performance side here, I believe the usability for devs is an important factor. Let the users who really need that last bit of perf opt-in, and let everyone else just go along in blissful ignorance. And I am honestly alright if "opt-in" means use preact or some other project.
Think about the reasons jQuery and WordPress were popular, despite performance issues, they JUST WORKED for people. React is the jQuery of vdom projects, don't try to make it the something it is not.