I run a few Amazon stores with about 10,000 SKUs -- don't re-SKU, what you want to do is brand gating... IF you are the brand owner and/or manufacturer. I can give you a few tips if you just need some advice. I'm guessing you don't have a vendorcentral account manager, but if you do, they can VERY effectively start banhammering the 3P knockoff companies.

Also, check out sellercentral forums for a community of folks there too. It's not HN but it's pretty active.