I used to (and still occasionally) suffer from staring out into the stars at night and realizing how insignificant I am. We should all be like Zaphod, eh?
Just remind yourself that life in an absurd universe is pointless, so there's no need to achieve anything beyond having a nice snack and a beer this evening.
To be honest, the thing that's most improved my happiness is exercise. It wasn't that long ago I (re)discovered the joy that you can observe on the faces of small children when they run for the sake of feeling their muscles move.