Not to say they didn't deserve it, but the entire American south basically had to reboot. Some states figured it out (Virginia, North Carolina, Georgia), and others haven't done as well (Mississippi, Alabama, Tennessee).
I don't follow. Certainly the current farming system in the American mid-west is orders of magnitude more productive. But even if we're focussed on pre-industrial history, are you sure that the ancient South American agri-economies weren't better? And for productive land use, what about Japan and south-east Asia, where every square inch ran like clockwork.
Tennessee and much of Appalachia has been historically on the side against slavery and corporate interests until somewhere around 60 years ago. I don't know how it happened besides hand-waving "Southern Strategy."