Fuel, jet fuel.
Biology doesn't produce the wheel.
Tumble weeds? Insects which curl up into a wheel to quickly roll away from danger? Can a car drive up stairs?
Indeed if we genetically engineered a large animal to run on gasoline AND provided it with an ample supply of gasoline, it would move faster than anything else... as long as it had gasoline.
If we engineered a bacterium to eat oil and/or gasoline and dispersed in the gulf.... already there, eating oil, consuming the oxygen in the water in the process.
If we added it to an oil well... already there, lots of bacteria deep within the earth, eating everything from metal to methane. Probably not consuming the world's oil reserve only for lack of oxygen or any other oxidizer.
...some possibilities, some terrifying.
Ebola, HIV, the flu de jour all quite terrifying, all 100% natural.
And unlike you, they don't care. They will keep evolving and trying to kill you as fast and as hard as they can, every minute of every day.