'Top-down' is actually why data management is still the way it is. Our handling of the primitives (think bottom-up approach) that build up to how things are structured at the higher level is still subpar at best, resulting in the massive inconsistencies, scaling issues and data integrity problems we face daily. Neurons (near-atomic components), from the biological sciences are still being compared analogously with more complex data structures in computing, raw grapes and wine style. Per being a technology problem, the question was about area/market segment requiring a breath of fresh air, not particularly what technology needs to be deployed.