I've always thought it'd be nice to build a sort of hybrid between a "ClojureScript for bash", and a Java boot-script + RPC client.
Picture a Clojure macro library just for writing CLI driver programs, where you could call all your Clojure code like normal, and where some of the subcommand-defining methods of the driver program could be annotated with something like "@inline".
The un-annotated subcommands, as a simpler case, would translate into calls to spawn a JRE and feed your ARGV over to it once it gets running. These would be the slow-startup calls, so you'd just use them for the things that need the full "horsepower" of the JVM.
The @inline subcommands, on the other hand, would grab your app, its deps, and the JRE, do a whole-program dead-code-elimination process over them to trim them down to just what that subcommand needs, and then would transpile that whole resulting blob to bash code and shove it into a bash function. (So, something like Emscripten with a different frontend + backend.)