Sometimes no options is better than many options.
When node 0.2.0 is released, we will have a lot more stability in node-core (though things are getting there now). Until then, this is still an "edge" project and should be treated accordingly. For instance, check out the recent addition of buffers and unification of stream interfaces.
There are web frameworks but it's not really much trouble to roll your own, tailored to your needs. Depends on your time budget of course. I'd love to see a high-level Rails-esque framework using node-machine, but there isn't one yet.
[1] http://github.com/tautologistics/nodemachine
[2] http://bitbucket.org/justin/webmachine/wiki/Home
[3] http://bitbucket.org/justin/webmachine/wiki/BigHTTPGraph