It would be possible if there was a general perception that men were generally and historically, in the context in which one is an activist, oppressed based on their sex, such that being an activist for greater rights for men was consistent with pro-equality interest rather than anti-women interests.
However, there are very few societies on the world where that view is dominant or even a wide minority view, either internally or for external observers, so it's very hard to be a "men's rights activist" without the general perception being that one is acting out an anti-woman worldview.