Hey, just to give you a trailhead into a service that I've used before for automatic ad-placement optimization, try Ezoic (ezoic.com). They did very well for me (150% increase in Adsense revenue) and their site says on average they double Adsense earnings. It's totally legit, they're a publishing partner with Google, which is eventually what made me sign up with them after some initial skepticism. But they delivered for sure.