It's not really the trip that worries me, it's living on Mars. You need to live under five meters of soil in order to get the same radiation protection as Earth's atmosphere provides. You're basically mole people. Which means the difference between living on Mars and living in windowless apartment complex on Earth is that you can do a couple space suit jaunts through the Martian deserts each week.

People can definitely survive living almost entirely indoors. I expect VR will be big on Mars. But I think the lack of natural light will really limit the comfort level.

If someone can invent an invisible electromagnetic radiation shield that would change the game.