Basically, no. It is 50% of the loaded labor rate of all employees doing R&D activities on projects that your liaison agrees qualify as R&D. When you work out of your home, rent/mortgage on your home are specifically excluded as business expenses (by CRA), so they can't be included. Working out of an office, you get about 65% of salary back; out of a basement (my situation), it is basically 50% of salary.

Oh -- hardware purchases and the like don't count, and you have to be able to prove the salary was paid, so as far as I know there is no game to be played with stock options.