This goes for a lot of that stupid shit people who barely know each other seem obligated to say at each other in the office. No one needs it. I mean just a polite nod acknowledging one's existence is fine, or maybe a "Good Morning". Let's stop all this "How are you?" with people we aren't even on a first name basis with. I mean do you really want to know the answer?
And if you don't know a person well enough to know if they're mad or they just look a certain way while they're deep in thought or rushing off somewhere, then don't say anything. It's _totes annoying_ and presumptuous. You saying a kind word while passing in the hallway is not going to magically unfuck someone's day.
Although holding doors when lugging laptop bags and so forth is always appreciated. Please continue to do this if you do. That just might unfuck someone's day a little bit.