They might not be intended to be, but from their dev site:
"Estimote Beacon is a small computer. Its 32-bit ARM® Cortex M0 CPU is accompanied by accelerometer, temperature sensor, and what is most important—2.4 GHz radio using Bluetooth 4.0 Smart, also known as BLE or Bluetooth low energy."
And from here: http://makezine.com/2014/01/03/reverse-engineering-the-estim...
"The Estimote is built around the Nordic Semiconductor nRF51822, which explains their presence on the Nordic booth at CES. It’s a nice chip, basically a 32-bit ARM Cortex M0 CPU with 256KB of flash and 16KB of RAM with a built-in 2.4GHz radio supporting both Bluetooth LE as well as 2.4GHz operation—where the 2.4GHz mode is on air compatible with the nRF24L series products from Nordic."
They might not be "easily programmable", but how much would you be against Travis Goodspeed being able to do something similar to what he's done here with an Estimote beacon? http://travisgoodspeed.blogspot.com.au/2011/02/promiscuity-i... (You can't see it very well in the image in the Makezine article of the board, but under the "CH3" in the label for the smaller chip is a 4 pin header that I'm 99.9% sure will be a jtag header...)