The good part is that if you are working on something you care about, you won't be as upset when you fail if you were building something just to become the next Zuck.
> The good part is that if you are working on something you care about, you won't be as upset
This probably varies from person to person, but failing at something I care about would make me much more upset than failing at something I didn't really care about.
I think he means if it's important to you it's still worth trying and if you fail at least you were trying. Whereas if it's just a business, "nothing personal," then failing means you've got nothing, not even the feeling of working on something important to you.