It is easy to do in many cases. Take the following two theories:
Rocks falls downwards since masses attracts each other.
Rocks falls downwards due to invisible ghosts making masses attract each other.
Both of these theories have the same amount of evidence supporting them, but one is strictly simpler than the other. If one theory isn't a simple reduction of the other then Occam's razor doesn't apply, but in those cases it is usually possible to make experiments which disproves one of them.