When I was in high school, I had a part time job/internship doing QA and writing some software. I was recruited there by my friend, who was blind, a programmer, and also in high school.

He was a great programmer, and very adept at using his screen reader. As far as I know, it only ever gave him one serious complication: since he was a minor, it was set to safe-for-work mode, and it read his coworker's name, a Mr Livshits, as Livsugars.