Other comments have already talked about what mindfulness meditation is but that's only a part answer.
You could say it's not different, since anything done in that physical pose is something we're going to call meditation. There are a lot of different practices from different cultures, and really what they have in common is that you quietly sit and focus on being in a certain state of mind, continuously trying to bring yourself back to that state of mind if/when you get distracted.
For mindfulness it's non-judgemental awareness of the present moment and your own mind's activity
For zen it's controlled focused attention on the object of meditation (nothing at all in the cliche)
For compassion meditation it's compassion/kindness/love towards yourself/others/everything
For the various types of body awareness meditation it's your own feeling of your physical body
There are mantras and guided meditation and many others, with a lot of historical cross pollination and tons of wacky woo-filled stuff. Many types that are likely complete junk that's useless or harmful because the whole edifice is built on magical thinking.
I think the feasible technical explanation is pretty simple, "neurons that fire together, wire together". It seems very reasonable to me that practising attaining a certain state of mind will make it easier to do at will and/or make shift your normal state in that direction. A lot of it is literally as simple as learning "If I focus on X for a short time I feel like Y, so now I know how to feel like Y when I want"