Pointing out the existence of a worse legal poison is not a very good argument for the legalisation of another one. Perhaps it should not be used at all.
Another argument is the incredible damage that drug prohibition has done to our society. Millions of drug users have been criminalised and/or jailed just because they wanted to alter their state of mind. Drugs on the street are often tainted with adulterants. Violent drug cartels have wreaked absolute havoc on entire countries.
The war on drugs does not work, so let's take a fresh approach.
GordonS> "Millions of drug users have been criminalised"
Well yes, they are criminals who have broken the law. Your argument is defeatist; drug prohibition works quite well in places like Japan and Singapore.