This perfectly summarizes the bitwise-innumeracy of the argument against UUIDs. Even without 128 bit word sizes, most UUIDs are going to be non-matches in their lower bits, assuming a random distribution. There's no computational efficiency gained in the vastly wide critical path here.
I hope you mean bytes. On a 128bit architecture that would be a single instruction compare, just like a 32 or 64 bit compare. Performance would be roughly the same (minus maybe a cache miss because you blew it out with your fat ints).
