> I'm sorry to hear that story. I hope this doesn't come off cruel because it isn't meant to be, but there are always outliers -- people for whom the gold standard, or any standard, just doesn't work.
I urge caution. The Chief 20+ years ago was darned well informed. Talk therapy and anxiety disease had been going for most of the 20th century. I don't know when cognitive approaches started, but, since they are an obvious approach, gotta guess that they have been understood for a long time.
> It's not a good idea to dismiss a well-studied treatment universally shown to be effective because we don't know if it'll work in a specific case.
Right, "dismiss" would be wrong. Trying it as a first step, if only since it's relatively easy and just a mild intervention, sure.
If you and the NLM, etc. link are correct, then it's news in the last 20 or so years.
From the Sheehan data, the Chief, and some more evidence, I have to guess that often, not just for an outlier, genetics can be an important cause. Sure, even then, maybe something cognitive can help one compensate.
My main point here is simple -- IMHO, the OP looks too simplistic.