That was the consequence of users switching to S/R years before.
https://www.jstatsoft.org/article/view/v013i07/v13i07.pdf
Users of maths software usually don't want to use Lisp syntax and are not ready to work in Lisp.
XLisp-Stat had also the problem that it used its own Lisp implementation, based on XLisp (upto Xlisp 2), which itself wasn't going anywhere. David Betz, the original author of Xlisp, rewrote Xlisp as a form of Scheme (Xlisp 3.0) and it died eventually. Xlisp-Plus, another Xlisp version, was mostly abandoned also in that timeframe - though there are updated versions available now.
Other math software, which had been ported to Common Lisp, is still maintained - like Maxima. The maintainers can concentrate on the application and the code is much easier portable to new systems because of a choice of implementations.
Had XLisp-Stat been fully ported to Common Lisp (actually a rough port of the Xlisp-Stat core to Common Lisp was done many years ago) and maintained there - at least the code would still be easier usable.