Let's say you distribute a binary over NFS -- compile some C or C++ or whatever you like. Then various hosts run /path/to/binary. At some point, the NFS server changes that file out from underneath those hosts, because, well, it can. The usual "text file busy" you'd get when trying to do that on a local filesystem never happens.

At some point after that, the hosts running the binary will try to page something involving that binary and will SIGBUS and die.

That's just one of many failure modes.