Is Shedskin still actively maintained? I haven't looked in a long time but last I saw it hadn't gotten any updates in a couple years (maybe I have corrupted memory though ;)

Anyhow, the relatively new Nuitka project seems to be aiming to tackle the python-to-c++ compiler problem, and seems to have a lot of promise. Really good compatibility, apparently decent speedups, and cross platform support. Works into Python3 too. I have a lot of hope!