For real publishing, I think TeX is still the state-of-the-art. It still produces the best-looking documents put on paper (granted, one needs to give it a decent font to do so…).
Pity that it's so difficult to do, say, bilingual books with one language on one side and the other on the other, with page elements lined up neatly. For that, Word is probably the easiest — but it looks terrible.