Did some resistance training a few years ago - felt good, lost fat while doing it.
Shifted to cardio for a few years with an employee sponsored cardio-centric wellness program. Experienced a gradual fat gain and knee and back pain, although I was running 20-30 miles per week, using far too much time per week.
Shifting back to weights the last few months. Not being very rigorous, but doing the exercises in "Starting Strength". Back pain* and knee pain now very infrequent. Strength is increased. Some muscle definition improvement (though lots of excess fat still).
* Lower back pain actually made me very hesitant to do deadlifts. I started with the bar and the very lightest weights and gradually progressed, being VERY cautious about strain on the lower back. I'm only dead lifting ~200 lbs at this point, but my back is much happier.