Check this out https://github.com/joshhunt/reactapus/blob/master/src/server.... Koa or Express.js wouldn't really make that much of a difference.
Although saying that, if I had chosen Koa.js the stack would have to be called 3REK, or 3RKE :/
I use the auto-transpilation trick with Babel. You can see a small example in my repo: https://github.com/odiroot/songs-to-spotify/blob/master/src/...
Then in required modules you're free to use ES2015.
what are its merits?
React - first commit May 29, 2013
Flux - first commit July 23, 2014
ExpressJS - first commit July 31, 2012
RethinkDB - first commit Oct 3, 2009
Yeah, I doubt it.