> Intent-driven ads are far more relevant to a site's audience than hand-picked, static ones. They have much higher CTR and conversion rates, when done right.

Not in my experience. My hand-picked ads are alway at a higher CTR than programmatic. Intent-driven programmatic gives me a 2x CTR over random static ads. Hand tuned gives me about 10x more CTR.

You may be able to optimize down a set of hand-picked ads programmatically, but you still need that manual curation in the process.

More important is losing your audience to a bad user experience via programmatic ads when they visit your site.

Also, I'm pretty sure Vogue or the advertisers use DoubleClick as just the ad hosting network for analytic purposes. They are likely sold on a display basis in Vogue.