Problems with HOL blocking can be reduced significantly with good caching though. 50 blocking requests aren't much of an issue if they're all going to return small "304 Not Modified" responses straight out of the web servers file cache.
And don't forget you can still get HOL blocking over HTTP/2... at the end of the day the browser has to start parsing HTML before it knows what else it needs to request. The only alternative is teaching your web server HTML or a set of heuristics and doing PUSH. And PUSH actually counter-acts the good in caching because when I load your index.html the web server has no idea whether I have jquery or your blogs stylesheet cached or not.
What I really want when I visit a URL is for my browser to tell the web server when I last visited, and then for the web server to give me a complete list of all dependent resources and sub-resources that have changed since that visit.... basically a set of HEAD responses that constitute a diff. My browser can then just say "hmm, ok, I needed these last time, and they've changed, so while I'm downloading index.html I'll just go ahead and request this and this and this even though I have no idea how I'm going to load them yet".
Basically, imho, all webpages should be cached as git repos ;)
Obviously that requires a decent server implementation that uses smallish sending chunks and doesn't over buffer.
So the browser should not reorder requests and hold some back (they all do play those games in h1) with h2 - it should just set the pri/dep flags well to give the server (which is going to do the sending) maximum information.
The real HOL problem with h2 involves TCP loss recovery. Its a fairly minor issue though in practice.
And that is I still need to wait 100-200ms for PHP to spit out HTML from index.php, 100ms for the client to receive it, and another 100ms for a list of prioritised requests for dependent resources to come back. How is that not a "real HOL problem"?
If you treat a request as referring to a bundle of resources rather than a single response then you can solve all that by allowing the client to send a lot more metadata about its current view of the whole package. This frees up the web server to respond with logo.png, funkystyle.css and bloated.js, or a freshness response, while we wait for PHP
The only way a user-agent can solve this under HTTP/2 is to request a bunch of related resources it knows it needed the last time, at a low priority, and hope they are either needed, or unneeded but unchanged (as to not waste bandwidth). And you know, a pipelined HTTP/1.1 client can do this just fine by prefacing its primary request with a bunch of If-Modified-Since requests.
And sure, you can build a webserver that can parse HTML out of PHP and do HTTP/2 PUSH, but again that's a waste of bandwidth if I have these resources cached.
That's why I think it's time to move away from a simple request, response and cache model and start thinking in terms of bundle synchronisation and dependencies.